Effect of Pulsatility on the Transport of Thrombin in an Idealized Cerebral Aneurysm Geometry

Computational models of cerebral aneurysm thrombosis are designed for use in research and clinical applications. A steady flow assumption is applied many these models. To explore the accuracy this a pulsatile-flow thrombin-transport computational fluid dynamics (CFD) model, which uses symmetrical idealized geometry, was developed. First, steady-flow model developed validated using data from an vitro experiment, based on particle image velocimetry (PIV). The experimental revealed asymmetric pattern aneurysm. subsequently altered to incorporate pulsatility, by applying data-derived function at inlet boundary. For both pulsatile models, scalar simulating thrombin generation wall. determine influence pulsatility transport, outputs were compared model. comparison that case, average 10.2% less accumulates within than case any given time, due periodic losses significant amount thrombin-concentrated blood into parent vessel’s bloodstream. These findings demonstrate may change clotting outcomes aneurysms.